CASE REPORT Cryofibrinogenemia with Polyarthralgia, Raynaud's Phenomenonand Acral Ulcer in a Patient with Graves' Disease Treated with Methimazole
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چکیده
Cryofibrinogenemia is a cryopathy in which hypersensitivity to cold is a prominent feature. Cryofibrinogenemia developed in an 18-year-old Japanese female patient during methimazole therapy for Graves' disease. She developed cryopathy (livedo reticularis, Raynaud's phenomenon and acral ulcer) and polyarthralgia during methimazole therapy, and we detected cryofibrinogen in her plasma. Her symptomsresolved after administration of prostaglandins and anticoagulants. Several reports indicate that methimazole therapy induces autoantibody-related disease. In the present case, we cannot exclude the possibility that methimazole therapy contributed to the cryofibrinogenemia. (Internal Medicine 36: 439-442, 1997)
منابع مشابه
Arthritis Associated With Low Dose Methimazole Therapy: A Case Report.
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